Neurobehavioral impacts and sociabilty and preference for social noverlty of wistar rats after treatment with neonicotinoide (Imidaclopride)

Abstract

The aim of this work is to study the effect of neonicotinoid insecticides on rat brains. In this work we examined the effect of imidacloprid in different doses (5 and 50 mg / kg / day) on the level of receptors for brains such as total proteins, carbohydrates and fats, and on the rate of enzymatic activities GST, GPx, CAT, and there was also interest in studying mitochondria and its permeability in rat wistar. Our results showed that imidacloprid causes an increase in proteins and a decrease in carbohydrate and fat levels. Regarding enzymatic activities, our results showed a noticeable decrease GST - GPx - AchE and a significant increase in CAT. As for non-enzymatic activities, it showed an increase in the index of GSH and MDA in the rat brain. Finally, our study indicates that there are very noticeable effects on nervous behavior, socialisation, and social preference for rat wistar after treatment with neonicotinoid (imidacloprid).